Adaferin (Adapalene Gel 0.1%) is a topical retinoid primarily used for the treatment of acne vulgaris. It works by modulating skin cell turnover and reducing inflammation to clear existing breakouts and prevent new ones from forming
Sirolimus is used for prevention of kidney transplant rejection. Sirolimus is an immunosuppressant. It works by suppressing your body's immune response following transplant of an organ (eg. liver, kidney, heart).