Adaferin (Adapalene Gel 0.1%) is a topical retinoid primarily used for the treatment of acne vulgaris. It works by modulating skin cell turnover and reducing inflammation to clear existing breakouts and prevent new ones from forming
Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Lowering blood pressure can reduce the risk of strokes and heart attacks. Spironolactone is also used to lessen the need for hospitalization for heart failure.