Adaferin (Adapalene Gel 0.1%) is a topical retinoid primarily used for the treatment of acne vulgaris. It works by modulating skin cell turnover and reducing inflammation to clear existing breakouts and prevent new ones from forming
Methotrexate is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body's immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells.