Adaferin (Adapalene Gel 0.1%) is a topical retinoid primarily used for the treatment of acne vulgaris. It works by modulating skin cell turnover and reducing inflammation to clear existing breakouts and prevent new ones from forming
It also can be used to terminate pregnancy resulting from undesired mating and to treat conditions associated with prolonged luteal function (e.g., pyometra, luteal cysts). Cloprostenol has been used to terminate pregnancy in any animal that forms a corpus luteum.